Land with Home for Sale in Defiance, Missouri

Looking for the perfect multi-generational home or private in-law suite with its own entrance? This custom-built Lombardo Ranch on 5.44 acres checks every box. Thoughtfully designed with high-end upgrades throughout, this home blends style, comfort, and function in every detail.

On the main level, you’ll find a chef’s kitchen featuring white custom cabinetry, quartz countertops, a striking stone arch over the cooktop, and premium appliances. Floor-to-ceiling windows flood the open living area with natural light, accentuating the hardwood floors, soaring ceilings, and custom finishes. The main level also includes the primary ensuite and two additional bedrooms, plus designer details such as smart-home technology, custom closets, and even a private cocktail lounge. The lower level lives like its own home, offering a full luxury kitchen, spacious living room, private study, and an additional primary suite—all with its own separate entrance. Perfect for multi-generational living, guests, or extended stays. Step outside to enjoy the serene setting—whether you’re relaxing on the covered cedar deck, unwinding on the patio, or envisioning a future pool in the private, level backyard framed by mature trees. All this, just minutes from wine country and within 10 minutes of the Hwy 40 corridor.